Last revision: 02-13-24 By Eugene L. Heyden, RN “Key to dismal clinical treatment is the unique tumor micro-environment (TME), especially abnormal tumor mechanics, associated with PDAC [pancreatic ductal adenocarcinoma]. It is well-documented that PDAC has an abundant stroma with overactivated cancer-associated fibroblasts (CAFs) and massive extracellular matrix (ECM). Together with the fast-proliferating cancer cells, extremely…