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The First Chapter
The Impact of Vitamin D Deficiency
Vitamin D deficiency is not benign. It has devastating consequences. In this book we take a hard look at the damage caused by what should be regarded as a hormonal deficiency. Over 1000 genes are regulated by Vitamin D–genes that promote health and defend against disease. The risk of chronic illness is dramatically elevated when Vitamin D is depressed. We will listen to what the experts have to say and what advise they have to offer.
Mommy, Me & Vitamin D
In this book we will take a good hard look a the damage done to our children by a simple little thing. Vitamin D deficiency is a simple little thing but with very serious consequences. It is a preventable cause of so much tragedy and so much heartache. If you are in the business of creating the next generation and have an interest in doing it right, this book is for you. You won’t want to put it down!
Preventing Birth Defects
Iodine deficiency and thyroid dysfunction are both commonplace, and during pregnancy place Baby at great risk for a variety of birth defects and unfavorable neurological outcomes. Autism and cerebral palsy serve as examples. In this book I will reveal the nature of the threat and outline preventive measures. I will present a compelling case for both iodine supplementation and universal screening for thyroid hormone abnormalities.
More To Consider in The Battle Against Crohn's
Crohn’s is a devastating disease. It can affect any part of the gastrointestinal tract causing pain, bleeding, and extensive tissue damage. MORE TO CONSIDER IN THE BATTLE AGAINST CROHN’S explains in layman’s terms what this disease is all about and offers suggestions on how to treat it more effectively.
More To Consider in The Battle Against Ulcerative Colitis
In the book you will learn so many things about ulcerative colitis you never knew you never knew. In the book you will be introduced to many alternative and complementary therapies available for the treatment of this disease.
War Stories: Stories of Success in The Battle Against Crohn's and Ulcerative Colitis
In this book, discover a lifeline for those gripped by Crohn’s or ulcerative colitis. A compassionate Registered Nurse shares a journey to fill knowledge gaps, revealing alternative paths to remission. Real case stories spotlight unconventional victories, offering hope. Collaboration with a physician is emphasized, guiding readers and medical professionals toward unexplored solutions.
The Impact of Vitamin D Deficiency
Chapter 1
Vitamin D: A natural history
Vitamin D: A natural history
- “Vitamin D is one of the oldest hormones that have been made in the earliest life forms for over 750 million years.” ~Holick, 2003
- “In terms of human history, humans were not confronted with vitamin D deficiency until the industrial revolution began.” ~Holick, 2003
- “Calling vitamin D a “vitamin” is something of a misnomer. Although the name is still used for historical reasons, vitamin D is more properly classified as a secosteroid because it consists of a cholesterol backbone and exerts steroid-like effects throughout the body, directly affecting the expression of over 1000 genes through the nuclear vitamin D receptor.” ~Cekic et al., 2011
Mommy, Me & Vitamin D
Chapter 1
Before you know it
Before you know it
- “This . . . hormone also regulates the expression of a large number of genes in reproductive tissues implicating a role for vitamin D in female reproduction.” ~Grundmann and von Versen-Höynk, 2011
Because of its steroid structure and function, vitamin D plays an important role in priming cells for other hormones to do their action.” ~Kaushal and Magon, 2013 - “Vitamin D deficiency during pregnancy is of epidemic proportions, present in ~20%–85% of women, depending on country of residence and other factors.” ~Shin et al., 2010
- “Pregnancy loss is one of the most common obstetric complications, affecting over 30% of conceptions. Most of these occur early in gestation, are due to problems with implantation and may not be clinically apparent. “~Silver, 2007
- “There is evidence that vitamin D regulates key target genes associated with implantation, trophoblast [recently fertilized egg] invasion and implantation tolerance.” ~Grundmann and von Versen-Höynk, 2011
Preventing Birth Defects
Chapter 1
It’s all about you
It’s all about you
- “Pregnant women are particularly vulnerable to iodine deficiency because early pregnancy is characterized by a rapid surge in thyroid hormone production (and iodine requirements). Late pregnancy also stresses maternal iodine stores because of increased renal clearance.”~Lockwood, 2013
- “The physiologic changes associated with pregnancy require an increased availability of thyroid hormones by 40% to 100% to meet the needs of mother and fetus.“~Feldt-Rasmussen et al., 2011
- “The availability of THs (thyroid hormones) is critical for brain development. A growing body of clinical and experimental evidence indicates that even slight decreases in serum [blood] levels of THs can have significant consequences on brain development.” ~Nucera, 2010, emphasis added
More To Consider In The Battle Against Crohn's
Chapter 1
Before you know it
Before you know it
- “Inflammation is a normal and vital protective response to the harmfulstimuli such as infectious agents, antigen-antibody reactions, thermal, chemical, physical agents, and ischemia [injury from low blood flow].” ~Kulkarni et al., 2006
- “The usual result of inflammation is protection from the spread of infection, followed by resolution—the restoration of affected tissues to their normal structural and functional state.
- “The problem with inflammation is not how often it starts, but how often it fails to subside. Perhaps no single phenomenon contributes more to the medical burden in industrialized societies than nonresolving inflammation.” ~Nathan and Ding, 2010, emphasis added
More To Consider in The Battle Against Ulcerative Colitis
Chapter 1
Nonresolving Inflammation
Nonresolving Inflammation
- “When a pathogen comes into contact with the host, a struggle [war] between the pathogen and the local innate host defense systems ensues. The resolution of this encounter is a critical determinant of whether the interaction leads to infection and overt disease.” ~Lu and Walker, 2001
- “Inflammation is a normal and vital protective response to the harmful stimuli such as infectious agents, antigen-antibody reactions, thermal, chemical, physical agents, and ischemia [injury from low blood flow].” ~Kulkarni et al., 2006, emphasis added
- “The usual result of inflammation is protection from the spread of infection, followed by resolution—the restoration of affected tissues to their normal structural and functional state.”
- “The problem with inflammation is not how often it starts, but how often it fails to subside. Perhaps no single phenomenon contributes more to the medical burden in industrialized societies than nonresolving inflammation.” ~Nathan and Ding, 2010, emphasis added
- “It appears that a central factor in virtually all inflammatory modulatory genes is NF-ĸB.” ~Neish, 2002
War Stories: Stories of Success in The Battle Against Crohn's and Ulcerative Colitis
Chapter 2
Crohn’s disease exclusion diet (CDED)
Crohn’s disease exclusion diet (CDED)
- The CD exclusion diet (CDED), is a whole-food diet coupled with PEN [partial enteral nutrition], designed to reduce exposure to dietary components, hypothesized to negatively affect the microbiome (dysbiosis), intestinal barrier, and intestinal immunity. It has shown promising ability to induce remission and decrease inflammation in case series in both children and adults with CD, including in patients with secondary loss of response to anti-tumor necrosis factor therapy. ~Levine et al., 2019
- The CDED, which avoided or reduced exposure to animal fat, dairy products, gluten, and emulsifiers and enabled exposure to fiber from fruits and vegetables led to remission in 70% of patients, primarily in patients with early mild-to moderate disease. ~Sigall-Boneh et al., 2014, emphasis added
- CDED is a long-term strategy that may be used as monotherapy, as combination therapy, for de-escalation of drugs, and as a rescue therapy for refractory patients. ~Herrador-López et al., 2010
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